Adenosine Deaminase Deficiency

Emergence definition

Severe combined immunodeficiency emerges from a weakened immune system, which is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines, leading to the accumulation of dATP.

Historical origin

Origin word

adenosine deaminase deficiency

Origin language

English

In other languages

• عوز نازعة أمين الأدينوزين ar primary
• Hereditärer Adenosindesaminase-Mangel German primary
• adenosine deaminase deficiency English primary
• Inmunodeficiencia combinada grave por déficit de adenosina desaminasa Spanish primary
• déficit immunitaire combiné sévère par déficit en adénosine désaminase French primary
• deficit di adenosina deaminasi it primary
• アデノシンデアミナーゼ欠損症 ja primary
• 腺苷脱氨酶缺乏症 zh primary

Prerequisites

What you need to understand first.

• Disease L5 (requires)
  Adenosine deaminase deficiency is a genetic disease causing severe immunodeficiency.
• Common Variable Immunodeficiency L6 (requires)
  common variable immunodeficiency is a core concept needed to understand adenosine deaminase deficiency
• Enzyme L16 (requires)
  Severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines.